96 Hour Chick Embryo Serial Section1/1/2023 ![]() ![]() Following contact, inductive interactions establish two cell fates within the blastema-the stromal progenitor cellsĪnd the nephrogenic mesenchyme ( Aufderheide et al. During the eleventh day postcoitum (dpc), the ureteric bud, an outgrowth of the Wolffian duct, contacts the metanephricīlastema. The ureteric bud and the nephrogenic mesenchyme (for review, see Saxen 1987). A model for the regulation of nephrogenesis byĭevelopment of the metanephric kidney depends on a program of reciprocal inductive interactions between two mesodermal derivatives, Because BMP7 is not produced by stromal progenitor cells, these data suggest a novel interactionīetween the nephrogenic mesenchyme and stromal progenitor cell populations. ![]() ![]() Interestingly, FGF2 and BMP7 also promote expansion of the stromal progenitor cell In addition, FGF2 and BMP7 signaling, both independentlyĪnd in combination, inhibit tubulogenesis. In conjunction with FGF2,īMP7 promotes growth and maintains competence of the mesenchyme in vitro. Mesenchyme cell population, however, is not competent to respond to signals promoting tubulogenesis. Studies presented here demonstrate that BMP7 signaling can prevent apoptosis in explants of metanephric mesenchyme. Shown that a loss of Bmp7function leads to kidney defects that are a likely result of progressive loss of nephrogenic mesenchyme by apoptosis. Population is maintained at the tips of the ureter in the presence of signals promoting tubulogenesis. Relatively little is known about the mechanism by which the nephrogenic mesenchyme cell During this period, new nephronsĪre continually being generated from a stem-cell population-the nephrogenic mesenchyme-in response to signals emanating from Nephrogenesis in the mouse kidney begins at embryonic day 11 and ends ∼10 days postpartum. ![]()
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |